He is known for his innovative and dynamic approach to architecture, which combines cutting-edge technology, sustainable design principles, and a deep interest in the relationship between space and human experience. Van Berkel's work often explores the integration of form and function, with an emphasis on creating structures that are both visually striking and highly functional.

UNStudio, which he co-founded with his partner Caroline Bos in 1988, has become internationally recognized for its avant-garde designs, ranging from cultural institutions and public spaces to private residences and commercial buildings. Ben van Berkel's designs often feature fluid, organic forms, incorporating advanced computational design and materials technology to push the boundaries of architecture. He is also a professor at various universities and a frequent lecturer, contributing to the ongoing dialogue about the future of architecture.

Van Berkel's work reflects a commitment to shaping the urban environment in ways that enhance social interaction, sustainability, and aesthetic innovation, positioning him as one of the leading figures in contemporary architecture.