Her objects are so many attempts to explore the incarnation of movement through lightness or surprise, while defending a demand for comfort and acceptance of bodies and their gestures.

After studying at ESSEC and Sciences Po, then a year at the Tokyo Parliament, Constance Guisset chose to turn to creation and entered ENSCI – Les Ateliers from which she graduated in 2007. In 2008, she received the Grand Prize for Design from the City of Paris, the Audience Prize at the Villa Noailles Design Parade and two VIA Project Grants. In 2010, she was named Designer of the Year at the Salon Maison & Objet and won the Audi Talents Awards.

Constance Guisset works with many French and international furniture publishing houses such as Petite Friture, Mustache, Tectona, Nature & Découvertes, Molteni&C, LaCividina, ZaoZuo, etc. The studio also designs industrial objects for LaCie - Seagate or jewelry for the MiniMasterpiece Gallery, for example.
His objects are now part of the collections of the FNAC (Duplex aquarium-cage), CNAP (Vertigo lamp) and the Georges-Pompidou National Center for Art and Culture (Leviosa lamp).

Since 2009, Constance Guisset has been creating scenographies for shows, notably those for the ballets Le Funambule, Les Nuits, La Fresque and Winterreise by Angelin Preljocaj, the concert by Laurent Garnier at the Salle Pleyel or the choreography Everyness by the company Wang Ramirez.
She also imagines exhibition scenographies for the Musée des Arts Décoratifs in Paris, the musée du quai Branly in Paris and the Palais des Beaux-Arts in Lille or for brands such as Galeries Lafayette and Molteni&C (2011, Prize for the best scenography, D'Days, Paris).
In 2021, she designs the permanent scenography of the Philharmonie des enfants within the Philharmonie de Paris and the permanent scenography of the modern art museum of Fontevraud.

Constance Guisset also designs interior architecture projects, including a restaurant at La Samaritaine in Paris for Groupe Ludéric (2021), collective spaces for Van Cleef & Arpels (2019) and for Accor (2014).

Since 2017, she has been illustrating and writing children's books, published by Albin Michel Jeunesse.

In May 2012, a first solo exhibition was dedicated to the work of Constance Guisset, at the Chapelle des Calvairiennes, Contemporary Art Center of the Pays de Mayenne. From September 2016 to January 2017, a retrospective takes place at the mudac (museum of design and contemporary applied arts) in Lausanne. A monograph was published on this occasion. An exhibition was dedicated to him at the Musée des Arts Décoratifs in Paris from November 2017 to March 2018.
In 2021, his work will be presented in a solo exhibition at Villa Noailles in Hyères (France). The French Institute in Milan will also dedicate an exhibition to his work in 2023.