In 1962 he founded the architectural firm Frank Gehry & Associates in Los Angeles. He designed the cardboard furniture series Easy Edges between 1969-72. Over the years he has taught at several universities, including Harvard and Yale, where he served as Charlotte-Davenport-Professorship of Architecture (1982, 1985, 1987-89) and where he still teaches.

Gehry has received numerous honorary doctorates from institutions including the University of Toronto, the University of Southern California, Yale University, Harvard University and the University of Edinburgh.